Searchable abstracts of presentations at key conferences in endocrinology

ea0098o9 | Other | NANETS2023

Prevalence of clonal hematopoiesis (CH) in neuroendocrine tumor (NET) patients prior to lutetium 177 Dotatate (Lu177): A prospective study

Bassam Sonbol Mohamad , Kusne Yael , Lasho Terra , Elsabbagh Zaid , Mangaonkar Abhishek , Ahn Daniel , Eiring Rachel , Hobday Timothy , Starr Jason , Bekaii-Saab Tanios , Patnaik Mrinal , Halfdanarson Thorvardur

Background: Lu177 has shown efficacy in advanced NET with significant hematologic toxicity, including therapy-related myeloid neoplasm (t-MN). CH is defined by acquisition of somatic mutations in hematopoietic stem cells with potential for expansion over time. In this study, we aimed to assess the prevalence of CH in NET patients (pts) prior to Lu177 along with the incidence of cytopenia in NET pts treated with lu177 based on the CH status at baselineMet...